Tuesday, October 5, 2010

Erectile Dysfunction and Magnesium

The range of pathologies associated with Mg deficiency include impotence (lack of NO)

It is pertinent to emphasize that magnesium promotes the synthesis of Nitric Oxide (NO), what will promptly lead to the amplification of cGMP cellular signalling, resulting in arterial dilation - as already discussed, this is the physiologic basis of penile erection.

Without magnesium, calcium will only deposit in the soft tissues and cause blockages. Magnesium acts as a calcium channel blocker and counteracts the negative effects of calcium in sustaining an erection.

Magnesium plays an important role in creating androgen, estrogen and the neurotransmitters that regular the sex drive.

Erectile dysfunction (ED) may be an early sign or symptom of cardiovascular disease (CVD)

Erectile dysfunction (ED) has traditionally been considered a disease that develops in patients with advanced systemic cardiovascular disease (CVD). However, evidence is accumulating that ED may be an early manifestation of systemic atherosclerosis and may precede the development of clinically significant vascular disease in other organs.

In one study, 64% of men who presented with myocardial infarction (MI) reported ED before the onset of heart problems.
Feldman HA et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61. | PubMed | ISI | ChemPort |

Similarly, 57% of men undergoing coronary bypass surgery reported ED prior to the operation.
Morley JE et al. Relationship of penile brachial pressure index to myocardial infarction and cerebrovascular accidents in older men. Am J Med 1988; 84: 445–448

Recent clinical research studies show that the presence or severity of penile vascular disease correlates with some cardiovascular risk factors. Chung et al3 found that the vasodilatory capacity of the penile vascular bed in patients with ED showed an inverse relation to the number of CVD risk factors, including the presence of diabetes.

Other investigators have reported a higher incidence of abnormal penile blood flow when the patient history includes risk factors such as previous MI, hypertension, or cigarette smoking.2,4,5
2 Morley JE et al. Relationship of penile brachial pressure index to myocardial infarction and cerebrovascular accidents in older men. Am J Med 1988; 84: 445–448.
4 Virag R, Bouilly P, Frydman D. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1985; 1: 181–184. | Article | PubMed | ISI | ChemPort |
5 Shabsigh R, Fishman IJ, Schum C, Dunn JK. Cigarette smoking and other vascular risk factors in vasculogenic impotence. Urology 1991; 38: 227–231. | Article | PubMed | ISI | ChemPort
Kawanishi et al showed that men with ED and an abnormal penile Doppler ultrasound exam are at increased risk for ischemic heart disease.
Kawanishi Y et al. Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients. Int J Impot Res 2001; 13: 100–103
Extracted from: International Journal of Impotence Research (2003) 15, 231–236. doi:10.1038/sj.ijir.3901012
Relation of C-reactive protein and other cardiovascular risk factors to penile vascular disease in men with erectile dysfunction

See: Your heart and Magnesium


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