Thursday, September 30, 2010

Cancer and Magnesium

Magnesium deficiency can directly lead to cancer. When you consider that over 300 enzymes and ion transport require magnesium and that its role in fatty acid and phospholipids acid metabolism affects permeability and stability of membranes, free radical generation, and glutathione depletion, we can see that magnesium deficiency would lead to a physiological decline in cells setting the stage for cancer.

Permeability of membranes
Anghileri et al proposed that modifications of cell membranes are principal triggering factors in cell transformation leading to cancer.
Anghileri, L.J. Magnesium concentration variations during carcinogenesis. Magnesium Bull. 1979; 1:46-48.
Anghileri, L.J., Collery, P., Coudoux, P., Durlach, J. (Experimental relationships between magnesium and cancer.) Magnesium Bull. 1981; 3:1-5

Scientists have in fact found out that there is much less Mg++ binding to membrane phospholipids of cancer cells, than to normal cell membranes.
Linus Pauling Institute

It has been suggested that Mg deficiency may trigger carcinogenesis by increasing membrane permeability.
In the case of solid tumors, a high level of supplemented magnesium inhibits carcinogenesis.
Blondell, J.W. The anticancer effect of magnesium. Medical Hypothesis 1980; 6:863-871.

Durlach J, Bara M, Guiet-Bara A, Collery P. Relationship between magnesium, cancer and carcinogenic or anticancer metals. Anticancer Res. 1986 Nov-Dec;6(6):1353-61

There is drastic change in ionic flux from the outer and inner cell membranes (higher Ca and Na; lower Mg and K levels), both in the impaired membranes of cancer, and of Mg deficiency.

Free radical generation and glutathione depletion

According to Dr. Russell Blaylock, low magnesium is associated with dramatic increases in free radical generation as well as glutathione depletion. This is vital since glutathione is one of the few antioxidant molecules known to neutralize mercury.
Glutathione helps to defend the body against damage from cigarette smoking, exposure to radiation, cancer chemotherapy, and toxins such as alcohol and just about everything else. Without the cleaning and chelating work of glutathione cells begin to decay as cellular filth and heavy metals accumulates; excellent environments to attract deadly infection/cancer.

Energy production

Mg2+ is critical for all of the energetics of the cells because it is absolutely required that Mg2+ be bound by ATP (adenosine triphosphate), the central high energy compound of the body.  ATP without Mg2+ bound cannot create the energy normally used by specific enzymes of the body to make protein, DNA, RNA, transport sodium or potassium or calcium in and out of cells, nor to phosphorylate proteins in response to hormone signals, etc.  In fact, ATP without enough Mg2+ is non-functional and leads to cell death.


Detoxification of carcinogenic chemical poisons is essential for people who want to avoid the ravages of cancer. Dr. Boyd Haley who asserts strongly that, “All detoxification mechanisms need Mg-ATP to drive the process.  There is nothing done in the body that does not use energy and without Mg2+ this energy can neither be made nor used.”

The involvement of free radicals in tissue injury induced by Mg deficiency causes an accumulation of oxidative products in heart, liver, kidney, skeletal muscle tissues and in red blood cells.
Virginia Minnich, M. B. Smith, M. J. Brauner, and Philip W. Majerus. Glutathione biosynthesis in human erythrocytes. Department of Internal Medicine, Washington University School of Medicine

Magnesium is a crucial factor in the natural self-cleansing and detoxification responses of the body. Without sufficient magnesium, the body accumulates toxins and acid residues, degenerates rapidly, and ages prematurely.

Magnesium protects cells from aluminum,
mercury, lead, cadmium, beryllium and nickel.

Immune system booster

Magnesium improves the internal production of defensive substances, such as antibodies and considerably improves the activity of white granulozytic blood cells (shown by Delbert with magnesium chloride), and contributes to many other functions that insure the integrity of cellular metabolism.

Studies on cancer and magnesium

·   Aleksandrowicz et al in Poland conclude that inadequacy of Mg and antioxidants are important risk factors in predisposing to leukemias.
        Aleksandrowicz, J., Blicharski, J., Dzigowska, A., Lisiewicz, J. Leuko- and oncogenesis in the light of studies on metabolism of magnesium and its turnover in biocenosis. Acta Med. Pol. 1970; 11:289-302. (abstr: Blood 1971; 37:245)

·   Other researchers found that 46% of the patients admitted to an ICU in a tertiary cancer center presented hypomagnesemia (Mg defiency). They concluded that the incidence of hypomagnesemia in critically ill cancer patients is high.
                D. Deheinzelin, E.M. Negri1, M.R. Tucci, M.Z. Salem1, V.M. da Cruz1, R.M. Oliveira, I.N. Nishimoto and C.    Hoelz. Hypomagnesemia in critically ill cancer patients: a prospective study of predictive factors. Braz J Med Biol Res, December 2000, Volume 33(12) 1443-1448

·   Researchers from the School of Public Health at the University of Minnesota have just concluded that diets rich in magnesium reduced the occurrence of colon cancer.
               American Journal of Epidemiology (Vol. 163, pp. 232-235)

·   A previous study from Sweden reported that women with the highest magnesium intake had a 40 per cent lower risk of developing cancer than those with the lowest intake of the mineral.
                Journal of the American Medical Association, Vol. 293, pp. 86-89

·   Pre-treatment hypomagnesemia has been reported
in young leukemic children, 78% of whom have histories
of anorexia, and have excessive gut and urinary losses of Mg.
        Paunier, L., Radde, I.C.: Normal and abnormal magnesium metabolism. Bull. of Hosp. for Sick Childr. (Toronto) 1965; 14:16-23.

·   Several studies have shown an increased cancer rate in regions with low magnesium levels in soil and drinking water, and the same for selenium. The main difference was an extremely high magnesium intake of 2.5 to 3g in cancer-free populations, ten times more than in most western countries.
        MAY 19, 1931, Dr. P. Schrumpf-Pierron presented a paper entitled “On the Cause Of the Rarity of Cancer in   Egypt,” which was printed in the Bulletin of the Academy of Medicine, and the Bulletin of the French Association for the Study of Cancer in July, 1931.

If we looked it would probably be very difficult to find a cancer patient with anywhere near normal levels of cellular magnesium meaning cancer probably does not exist in a physical cellular environment full of magnesium.

No one thinks to use it in cancer as a primary treatment. It is even worse than this, the medical establishment does not even use magnesium as a secondary treatment, or even use it at all and gladly uses radiation and chemo therapy, both of which force magnesium levels down further.

Magnesium chloride is the first and most important item in any person’s cancer treatment strategy. It goes against a gale wind of medical science to ignore magnesium chloride used transdermally in the treatment of any chronic or acute disorder, especially cancer.

During the first six months of treatment one should be looking at ten parts magnesium to one part calcium. In reality one need not even count the ratio during the first months, for the only real danger of extremely high magnesium levels comes with patients suffering from kidney failure.

It takes about three to four months to drive up cellular magnesium levels to where they should be when treated intensely transdermally but within days patients will commonly experience its life saving medical/healing effects.

Put in the clearest terms possible, our suggestion from the first day for cancer patients is to almost drown oneself in transdermally applied magnesium chloride.

Extracted from

Wednesday, September 29, 2010

Calcification and Magnesium

If calcium is not taken with magnesium it will cause much more harm than good. Unabsorbed calcium can lodge anywhere in our body. For instances, if it lodges in your bones and joints, it mimics arthritis; if it lodges in you heart, it mimics arterial lesions.

Calcification or calcium poisoning can manifest as heart disease, cancer, wrinkled skin, kidney stones, osteoporosis, dental problems, bone spurs, cataracts and many other health problems.

Calcium deposits in the joints are called arthritis; in the blood vessels it is hardening of the arteries; in the heart it is heart disease, and in the brain it is senility. A healthy cell has high magnesium and low calcium levels

Dr. Garry Gordon wrote, Whenever intracellular calcium is elevated, you have a relative deficiency of magnesium, so whenever anyone is seriously ill, acute or chronic, part of your plan must be to restore magnesium, which is poorly absorbed through oral means.”

Countries with the highest calcium to magnesium ratios (high calcium and low magnesium levels) in soil and water have the highest incidence of cardiovascular disease. At the top of the list is Australia. In contrast, Japan with its low cardiac death rate cites a daily magnesium intake as high as 560 milligrams.

Magnesium taken in proper dosages can solve the problem of calcium deficiency.
Dr. Nan Kathryn Fuchs, author of The Nutrition Detective

A healthy cell has high magnesium and low calcium levels. The higher the calcium level and the lower the magnesium level in the extra-cellular fluid, the harder is it for cells to pump the calcium out. The result is that the mitochondria gradually calcify and energy production decreases with low magnesium levels. Our biochemical age could theoretically be determined by the ratio of magnesium to calcium within our cells.

Cystic Fibrosis and Magnesium

Hypomagnesaemia in patients with cystic fibrosis (CF) is underrecognized. Many patients are asymptomatic, although severe deficiency may be associated with muscle weakness, cramps and tetany.
Hypomagnesaemia may be a risk factor for post-transplant complications including convulsions, which may be exacerbated by the use of calcineurin inhibitors.
Hypomagnesaemia is a common finding in patients with CF referred for lung transplant assessment. Serum magnesium levels should be monitored in all CF patients being referred for lung transplant irrespective of the results of other renal function tests.

(Magnesium) deficiency probably occurs with significant frequency in cystic fibrosis and should be considered in such patients so that important morbidity can be prevented.
PMID: 6648626 [PubMed - indexed for MEDLINE]

The removal of highly viscous mucus from the airways is an important task in the treatment of chronic lung disease like in cystic fibrosis.
Increasing the magnesium concentration in the airway surface liquid by aerosolisation of magnesium solutions or oral magnesium supplements could improve the removal of highly viscous mucus in chronic lung disease by activating endogenous DNase activity.
PMID: 19661013 [PubMed - indexed for MEDLINE].

Median salivary magnesium concentration and lactate dehydrogenase activity were significantly lower in CF patients than in the healthy controls.
Salivary profile and oxidative stress in children and adolescents with cystic fibrosis.
Livnat G, Bentur L, Kuzmisnsky E, Nagler RM.
Pediatric Pulmonary Unit, Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel.

Scalp hair of neonates with cystic fibrosis contains significantly elevated concentrations of sodium and potassium. Nearly all of the calcium and 80% of the magnesium in the hair of these patients may be extracted by washing or boiling the hair in water, whereas only a small fraction of the calcium and magnesium of the hair of healthy infants is water soluble.

The increased or decreased solubilities of calcium complexes have been previously observed in various tissues of patients with CF. The inability of hair from patients with CF to bind calcium and magnesium may be related to the basic defect in this disease.

Cystic fibrosis is disease that significantly impacts the lungs and the digestive tract. Because of genetic mutations, secretions become very thick leading to damage of the lungs, along with chronic inflammation and chronic infections.

The gastrointestinal tract is also affected because the digestive enzymes of the pancreas are not effectively released in to the intestines. Lack of digestive enzymes means that food is not properly broken down and digested. This leads to MANY nutritional deficiencies.

The problems for the CF patient include:

Lack of digestive power leading to many nutritional deficiencies including magnesium.
Low Concentrations of Sodium and Magnesium in Erythrocytes From Cystic Fibrosis Heterozygotes. Foucard, T., et al, ACTA Pediatrica Scand., 1991;80:57-61.
As lung capacity decreases, more vitamins will be used at an even faster rate.

The lungs are more prone to inflammation and thus more infections [Source: Keitcher].

Infections are often harder to clear.

Bowel issues: poorly digested food, constipation, diarrhoea, odorous stools.

Colonization of bad bacteria such as pseudomonas, a bug that is often very hard to treat and very hard to rid the body of.

Supplementation should focus on a program that includes vitamins E, A, K, zinc and magnesium.

Magnesium is needed for all muscles, including the chest wall and also to utilize essential fatty acids [Source: Tirouvanziam].

By controlling inflammation in the lungs, the body is much less prone to infection. (See: Inflammation and Magnesium)

The lungs are the organs that stand to get hit the hardest with more and more infections. These infections must be prevented so that antibiotic resistance does not develop and lung function can be maintained.

Glutathione provides significant benefit to the lungs.  The body actually makes glutathione as one of its major treatments critical for repair and detoxification. Glutathione requires magnesium for synthesis.

CF patients have been shown to be low in glutathione, particularly in the lining of the lungs.

In CF, lower levels of glutathione have correlated with poorer lung function [Source: Mangione].

Fatty stools cause malabsorption of calcium and magnesium. Many of the other problems of CF patients such as poor immunity, bronchospasm (asthma), heart problems, diabetes, poor growth, delayed puberty and abnormal genital development are due to these micronutrient deficiencies.

Magnesium deficiency is extremely common and should be treated as deficiency results in heart disease, bronchospasm and immune incompetence.


Alcoholism and Magnesium

Alcohol has always been known to deplete magnesium, and is one of the first supplements given to alcoholics when they stop and attempt to detoxify and withdraw.(

Magnesium (Mg) deficiency occurs frequently in chronic alcoholism and may contribute to the increased incidence of osteoporosis and cardiovascular disease seen in this population.

Mg deficiency is primarily due to renal Mg-wasting and is exacerbated by dietary Mg deprivation, gastrointestinal losses with diarrhea or vomiting, as well as concomitant use of drugs such as diuretics and aminoglycosides.

Osteoporosis is prevalent in the alcoholic population. Mg deficiency may contribute to increased bone loss by its effects on mineral homeostasis. In Mg depletion, there is often hypocalcemia due to impaired parathyroid hormone (PTH) secretion, as well as renal and skeletal resistance to PTH action. Serum concentrations of 1,25-vitamin D are also low. These changes are seen with even mild degrees of Mg deficiency and may contribute to the metabolic bone disease seen in chronic alcoholics.
Hypomagnesemia in alcoholics may also contribute to increased cardiovascular disease by altering platelet function. Mg deficiency has been demonstrated to enhance platelet reactivity. In these studies, Mg was shown to inhibit platelet aggregation against various aggregation agents. Patients with Mg deficiency were shown to have increased platelet aggregation that was normalized with Mg therapy.

The antiplatelet effect of Mg may be related to the finding that Mg inhibits the synthesis of thromboxane A2 and 12-hydroxyeicosatetraenoic acid, eicosanoids thought to be involved in platelet aggregation. Mg also inhibits the thrombin-induced Ca2+ influx in platelets, as well as stimulates synthesis of prostaglandin I2, the potent antiaggregatory eicosanoid. Therefore, Mg deficiency may increase platelet aggregation and cause increased hypertension and atherosclerotic cardiovascular disease in alcoholics.


Arthritis and Magnesium

ALL arthritis suffers have a deficiency of magnesium chloride, This is the same type of magnesium that occurs naturally in your cells. ...

The Arthritis Trust of America... well documented report of all his studies on Magnesium Chloride. ...
Magnesium: A Key to Calcium Absorption
By Nan Kathryn Fuchs, Ph.D.

Without magnesium, calcium may be not fully utilized, and underabsorption problems may occur leading to arthritis, osteoporosis amongst others.

Our bodies retain calcium and not magnesium although we tend to eat much more dairy than our ancestors. In addition, our sugar and alcohol consumption is higher than theirs, and both sugar and alcohol increase magnesium excretion through the urine.

Our grains have been refined, which means that the nutrient is lost in the process. The quality of our soil has deteriorated as well, due to the use of fertilizers that contain large amounts of potassium a magnesium antagonist. This results in foods lower in magnesium than ever before.


Magnesium is needed for calcium absorption. Without enough magnesium, calcium can collect in the soft tissues and cause arthritis. Not only does calcium collect in the soft tissues of arthritics, it is poorly, if at all, absorbed into their blood and bones.

But taking more calcium is not the answer; it only amplifies the problem. In fact, excessive calcium intake and insufficient magnesium can contribute to both of these diseases. Magnesium taken in proper dosages can solve the problem of calcium deficiency.

PTH draws calcium out of the bones and deposits it in the soft tissues, while calcitonin increases calcium in our bones and keeps it from being absorbed in our soft tissues. Because magnesium suppresses PTH and stimulates calcitonin it helps put calcium into our bones, preventing osteoporosis, and helps remove it from our soft tissues eliminating some forms of arthritis.

A magnesium deficiency will prevent this chemical action from taking place in our bodies, and no amount of calcium can correct it. While magnesium helps our body absorb and retain calcium, too much calcium prevents magnesium from being absorbed. So taking large amounts of calcium without adequate magnesium may either create malabsorption or a magnesium deficiency. Whichever occurs, only magnesium can break the cycle.

Dr. Guy Abraham, M.D., a research gynecologist and endocrinologist in premenstrual syndrome and osteoporosis has found when calcium intake is decreased, it is utilized better than when it is high. Dr. Abraham is one of many doctors and biochemists who advocate taking more magnesium to correct calcium-deficiency diseases.

Magnesium Builds Bones
One large study published in the American Journal of Clinical Nutrition found people who ate diets high in potassium and magnesium had higher bone density readings and stronger bones than those who didn’t.

“Magnesium is important for bone mineralization and many arthritis patients have demineralized bone, so it would benefit them to include lots of magnesium-rich foods in their diet,” says Carol Henderson, PhD, assistant professor at Georgia State University in Atlanta.

Magnesium Supplements Can Reverse Arthritis

Scientific studies show that magnesium supplements can reverse arthritis and osteoporosis!

However, many recent studies irrefutably demonstrate that magnesium supplements can not only reverse bone loss, but can actually rebuild your bone tissue. When magnesium supplements, in a 2:3 balanced ratio of calcium-magnesium are taken, bone density has increased by up to a startling 11% in just nine months!

As we age, certain nutrients are not as readily absorbed. Magnesium is just one of these. Magnesium deficiency effectively disables the hormone calcitonin, resulting in calcium being deposited in soft tissue and not into your bones.

Excess calcium stimulates the parathyroid hormone (PTH), which tells the body to pull calcium out of your bones and deposit the excess in soft tissues. This process is also implicated in arteriosclerosis.

Let’s look at the diets in several areas of the world and compare the rates of arthritis and osteoporosis to prove the case for magnesium supplements as a natural remedy.
v   The typical South African diet supplies a healthy 2:3 ratio of calcium to magnesium and these people have one of the lowest rates of arthritis and osteoporosis.
v   The typical American diet, rich in calcium, is typically in a 10:1 calcium-magnesium ratio and we have one of the highest rates of osteoporosis and arthritis in the world!
v   In Asian and African cultures, these conditions are relatively unknown.

The bottom line is that when calcium intake is high and
magnesium intake is low, these debilitating conditions are rampant.

What’s the answer? Decreasing your calcium intake and taking a daily magnesium supplement of at least 600mg, can produce dramatic results, in just nine months.

Magnesium Ion Helps Suppress Rheumatoid Arthritis Development, Akokasei Confirms

Tokyo (JCNN) - Japanese salt manufacturer Akokasei has announced the results of its latest research on brine water that richly contains magnesium ion (Mg2+).

In its recent experiments on rats with adjuvant arthritis (AA), the company examined how brine water affects the level of leg edema and indomethacin-induced gastrointestinal damage.

The results showed that leg edema and gastrointestinal damage have been suppressed in the group administered with brine water. Thus, the company concluded that Mg2+ has a potential to prevent the development of rheumatoid arthritis.

Details of the research results were presented at the 125th Annual Meeting of the Pharmaceutical Society of Japan.

Alzheimer's disease and Magnesium

Evidence is mounting that low levels of magnesium contribute to the heavy metal deposition in the brain that precedes  Alzheimer’s.

Mg values are found to be significantly decreased in brain regions of (Alzheimer’s) patients compared to the controls.                                                                                    Dr. E Andrasi
Andrasi E, Igaz S, Molnar Z, Mako S. Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease. L. Eotvos University, Budapest, Hungary. Magnes Res. 2000 Sep;13 (3):189-96.

Dr. J.L. Glick in 1990 showed a significant decrease in the frequency of intracellular magnesium deposits in neurons of Alzheimer disease patients as compared with control patients

Normalizing brain levels of magnesium may help fight deposition of aggregated beta-amyloid (Abeta) as seen in Alzheimer’s disease and related dementias
 (J Alzheimer Dis. July 2010;20(4):1091-1106. DOI: 10.3233/JAD-2010-091444).

Evidence is presented indicating that dementias are associated with a relative insufficiency of Magnesium (Mg) in the brain.
Med Hypotheses 1990 Dec;33(4):preceding 301.

Our data suggest that there is a relationship between serum Mg levels and the degree of Alzheimer’s disease and that the determination of the Mg level at various stages may provide valuable information in further understanding the progression and treatment of Alzheimer’s disease.

Undoubtedly the trigger mechanism of Altzheimer’s is the accumulation of heavy metals in the nervous system causing free radical damage leading to DNA and Mitochondrial DNA (mtDNA) damage.

In a human autopsy study, brain tissues from people with AD at death were compared with an age-matched group of control brains from subjects without AD. Mercury content was considerably higher in the AD group. Mercury concentration was prominent in the brain structures involved in memory function.

Many researchers feel that the actual cause of Alzheimer’s disease is due to toxic metal that leaches from mercury-silver amalgam dental fillings. Mercury vapor from amalgam fillings is absorbed into the sinuses and goes through the blood stream directly to the brain.

Vaccines as well as the air, water and food we eat all contain mercury.


Is neurotoxic even in minute quantities. Normally, the brain is protected form toxic substances by a membrane, the blood-brain barrier. However, because aluminum seems to be concentrated in brain tissue of Alzheimer's victims, it is assumed that there must be a defect in the barrier system permitting aluminum to enter.

Dr. Jean Durlach recognized fifteen years ago the importance of magnesium in the development of Alzheimer’s saying. “Numerous studies have revealed the increased presence of aluminum (Al) in brain tissue obtained from autopsies of Alzheimer disease patients.”

Mg depletion, particularly in the hippocampus, appears to represent an important pathogenic factor in Alzheimer's disease. It is associated with high aluminum incorporation into brain neurons - Dr.Jean Durlach

Dr. Glick suggests that Alzheimer's disease involves a defective transport process characterized by both an abnormally low Mg incorporation and an abnormally high Al incorporation into brain neurons.

Aluminum given to a healthy subject will bring on symptoms of tremors, forgetfulness, disorientation, a very dry, or weeping eczema and skin rashes, as well as other nerve and brain tissue disorders.

Magnesium protects cells from aluminium ,mercury, lead, cadmium, beryllium and nickel. Low magnesium is associated with glutathione depletion. This is vital since glutathione is one of the few antioxidant molecules known to neutralize mercury.

In an article recently published in the Journal of Orthomolecular Medicine, an Ontario study involving 668 autopsy-verified Alzheimer's brains, showed an increased risk by a factor of 2.5 in people drinking water with more than 100 micrograms of aluminium.
Blood brain barrier permeability:
The integrity and function of the BBB is critical for overall brain function. Changes in permeability often reflect alterations in BBB transport systems. Causes of generalized changes in BBB permeability include organic solvents, enzymes, heavy metals and free radicals.

Magnesium has an important role at the BBB and is the crucial nutrient that makes a big difference in prevention and treatment of Alzheimer’s disease

More benefits of Magnesium

Memory and the overall functioning of our brains depend on proteins in our brains called NMDA receptors, which allow our neurons to communicate with each other.

An understanding of the strategic importance of magnesium at these crucial NMDA receptor sites confirms the medical view that heavy magnesium supplementation would lead to better treatments for schizophrenia, Alzheimer’s disease, and stroke.

Magnesium permits calcium to enter a nerve cell to allow electrical transmission along the nerves to and from the brain. Even our thoughts, via brain neurons, are dependent on magnesium.
Dr. Carolyn Dean

Magnesium is essential in regulating central nervous system excitability. It calms the brain and people do not need to become severely deficient in magnesium for the brain to become hyperactive.

One study confirmed earlier reports that a marginal magnesium intake overexcites the brain's neurons and results in less coherence--creating cacophony rather than symphony--according to (EEG) measurements.

Of all the macronutrient minerals in the human body,
magnesium is the one most likely to be deficient.

Even a mild deficiency of magnesium can cause sensitiveness to noise, nervousness, irritability, mental depression, confusion, twitching, trembling, apprehension, and insomnia.

The two most basic requirements for the normal operation of our brain are a sufficient energy supply and an optimal presence of biochemicals involved in transmitting messages. Magnesium is crucial in both the production of energy and neurotransmitters and the integrity of the blood brain barrier. It is solid science that connects magnesium to neurological disorders.