Wednesday, September 29, 2010

Alcoholism and Magnesium

Alcohol has always been known to deplete magnesium, and is one of the first supplements given to alcoholics when they stop and attempt to detoxify and withdraw.(http://www.magnesiumforlife.com/)

Magnesium (Mg) deficiency occurs frequently in chronic alcoholism and may contribute to the increased incidence of osteoporosis and cardiovascular disease seen in this population.

Mg deficiency is primarily due to renal Mg-wasting and is exacerbated by dietary Mg deprivation, gastrointestinal losses with diarrhea or vomiting, as well as concomitant use of drugs such as diuretics and aminoglycosides.

Osteoporosis is prevalent in the alcoholic population. Mg deficiency may contribute to increased bone loss by its effects on mineral homeostasis. In Mg depletion, there is often hypocalcemia due to impaired parathyroid hormone (PTH) secretion, as well as renal and skeletal resistance to PTH action. Serum concentrations of 1,25-vitamin D are also low. These changes are seen with even mild degrees of Mg deficiency and may contribute to the metabolic bone disease seen in chronic alcoholics.
Hypomagnesemia in alcoholics may also contribute to increased cardiovascular disease by altering platelet function. Mg deficiency has been demonstrated to enhance platelet reactivity. In these studies, Mg was shown to inhibit platelet aggregation against various aggregation agents. Patients with Mg deficiency were shown to have increased platelet aggregation that was normalized with Mg therapy.

The antiplatelet effect of Mg may be related to the finding that Mg inhibits the synthesis of thromboxane A2 and 12-hydroxyeicosatetraenoic acid, eicosanoids thought to be involved in platelet aggregation. Mg also inhibits the thrombin-induced Ca2+ influx in platelets, as well as stimulates synthesis of prostaglandin I2, the potent antiaggregatory eicosanoid. Therefore, Mg deficiency may increase platelet aggregation and cause increased hypertension and atherosclerotic cardiovascular disease in alcoholics.

Source: www.nutramed.com/alcohol/alcoholref.htm

Arthritis and Magnesium

ALL arthritis suffers have a deficiency of magnesium chloride, This is the same type of magnesium that occurs naturally in your cells. ...

The Arthritis Trust of America... well documented report of all his studies on Magnesium Chloride. ...
Magnesium: A Key to Calcium Absorption
By Nan Kathryn Fuchs, Ph.D.

Without magnesium, calcium may be not fully utilized, and underabsorption problems may occur leading to arthritis, osteoporosis amongst others.

Our bodies retain calcium and not magnesium although we tend to eat much more dairy than our ancestors. In addition, our sugar and alcohol consumption is higher than theirs, and both sugar and alcohol increase magnesium excretion through the urine.

Our grains have been refined, which means that the nutrient is lost in the process. The quality of our soil has deteriorated as well, due to the use of fertilizers that contain large amounts of potassium a magnesium antagonist. This results in foods lower in magnesium than ever before.

ARTHRITIS AND OSTEOPOROSIS

Magnesium is needed for calcium absorption. Without enough magnesium, calcium can collect in the soft tissues and cause arthritis. Not only does calcium collect in the soft tissues of arthritics, it is poorly, if at all, absorbed into their blood and bones.

But taking more calcium is not the answer; it only amplifies the problem. In fact, excessive calcium intake and insufficient magnesium can contribute to both of these diseases. Magnesium taken in proper dosages can solve the problem of calcium deficiency.

PTH draws calcium out of the bones and deposits it in the soft tissues, while calcitonin increases calcium in our bones and keeps it from being absorbed in our soft tissues. Because magnesium suppresses PTH and stimulates calcitonin it helps put calcium into our bones, preventing osteoporosis, and helps remove it from our soft tissues eliminating some forms of arthritis.

A magnesium deficiency will prevent this chemical action from taking place in our bodies, and no amount of calcium can correct it. While magnesium helps our body absorb and retain calcium, too much calcium prevents magnesium from being absorbed. So taking large amounts of calcium without adequate magnesium may either create malabsorption or a magnesium deficiency. Whichever occurs, only magnesium can break the cycle.

Dr. Guy Abraham, M.D., a research gynecologist and endocrinologist in premenstrual syndrome and osteoporosis has found when calcium intake is decreased, it is utilized better than when it is high. Dr. Abraham is one of many doctors and biochemists who advocate taking more magnesium to correct calcium-deficiency diseases.

Magnesium Builds Bones
One large study published in the American Journal of Clinical Nutrition found people who ate diets high in potassium and magnesium had higher bone density readings and stronger bones than those who didn’t.

“Magnesium is important for bone mineralization and many arthritis patients have demineralized bone, so it would benefit them to include lots of magnesium-rich foods in their diet,” says Carol Henderson, PhD, assistant professor at Georgia State University in Atlanta.

Magnesium Supplements Can Reverse Arthritis

Scientific studies show that magnesium supplements can reverse arthritis and osteoporosis!

However, many recent studies irrefutably demonstrate that magnesium supplements can not only reverse bone loss, but can actually rebuild your bone tissue. When magnesium supplements, in a 2:3 balanced ratio of calcium-magnesium are taken, bone density has increased by up to a startling 11% in just nine months!

As we age, certain nutrients are not as readily absorbed. Magnesium is just one of these. Magnesium deficiency effectively disables the hormone calcitonin, resulting in calcium being deposited in soft tissue and not into your bones.

Excess calcium stimulates the parathyroid hormone (PTH), which tells the body to pull calcium out of your bones and deposit the excess in soft tissues. This process is also implicated in arteriosclerosis.

Let’s look at the diets in several areas of the world and compare the rates of arthritis and osteoporosis to prove the case for magnesium supplements as a natural remedy.
v   The typical South African diet supplies a healthy 2:3 ratio of calcium to magnesium and these people have one of the lowest rates of arthritis and osteoporosis.
v   The typical American diet, rich in calcium, is typically in a 10:1 calcium-magnesium ratio and we have one of the highest rates of osteoporosis and arthritis in the world!
v   In Asian and African cultures, these conditions are relatively unknown.

The bottom line is that when calcium intake is high and
magnesium intake is low, these debilitating conditions are rampant.

What’s the answer? Decreasing your calcium intake and taking a daily magnesium supplement of at least 600mg, can produce dramatic results, in just nine months.
http://www.mindreality.net/magnesium-supplements-can-reverse-arthritis

Magnesium Ion Helps Suppress Rheumatoid Arthritis Development, Akokasei Confirms

Tokyo (JCNN) - Japanese salt manufacturer Akokasei has announced the results of its latest research on brine water that richly contains magnesium ion (Mg2+).

In its recent experiments on rats with adjuvant arthritis (AA), the company examined how brine water affects the level of leg edema and indomethacin-induced gastrointestinal damage.

The results showed that leg edema and gastrointestinal damage have been suppressed in the group administered with brine water. Thus, the company concluded that Mg2+ has a potential to prevent the development of rheumatoid arthritis.

Details of the research results were presented at the 125th Annual Meeting of the Pharmaceutical Society of Japan.

http://www.medicalnewstoday.com/articles/24877.php

Alzheimer's disease and Magnesium

Evidence is mounting that low levels of magnesium contribute to the heavy metal deposition in the brain that precedes  Alzheimer’s.

Mg values are found to be significantly decreased in brain regions of (Alzheimer’s) patients compared to the controls.                                                                                    Dr. E Andrasi
Andrasi E, Igaz S, Molnar Z, Mako S. Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease. L. Eotvos University, Budapest, Hungary. Magnes Res. 2000 Sep;13 (3):189-96.

Dr. J.L. Glick in 1990 showed a significant decrease in the frequency of intracellular magnesium deposits in neurons of Alzheimer disease patients as compared with control patients

Normalizing brain levels of magnesium may help fight deposition of aggregated beta-amyloid (Abeta) as seen in Alzheimer’s disease and related dementias
 (J Alzheimer Dis. July 2010;20(4):1091-1106. DOI: 10.3233/JAD-2010-091444).

Evidence is presented indicating that dementias are associated with a relative insufficiency of Magnesium (Mg) in the brain.
Med Hypotheses 1990 Dec;33(4):preceding 301.

Our data suggest that there is a relationship between serum Mg levels and the degree of Alzheimer’s disease and that the determination of the Mg level at various stages may provide valuable information in further understanding the progression and treatment of Alzheimer’s disease.

Undoubtedly the trigger mechanism of Altzheimer’s is the accumulation of heavy metals in the nervous system causing free radical damage leading to DNA and Mitochondrial DNA (mtDNA) damage.

Mercury:
In a human autopsy study, brain tissues from people with AD at death were compared with an age-matched group of control brains from subjects without AD. Mercury content was considerably higher in the AD group. Mercury concentration was prominent in the brain structures involved in memory function.

Many researchers feel that the actual cause of Alzheimer’s disease is due to toxic metal that leaches from mercury-silver amalgam dental fillings. Mercury vapor from amalgam fillings is absorbed into the sinuses and goes through the blood stream directly to the brain.

Vaccines as well as the air, water and food we eat all contain mercury.

Aluminum:

Is neurotoxic even in minute quantities. Normally, the brain is protected form toxic substances by a membrane, the blood-brain barrier. However, because aluminum seems to be concentrated in brain tissue of Alzheimer's victims, it is assumed that there must be a defect in the barrier system permitting aluminum to enter.

Dr. Jean Durlach recognized fifteen years ago the importance of magnesium in the development of Alzheimer’s saying. “Numerous studies have revealed the increased presence of aluminum (Al) in brain tissue obtained from autopsies of Alzheimer disease patients.”

Mg depletion, particularly in the hippocampus, appears to represent an important pathogenic factor in Alzheimer's disease. It is associated with high aluminum incorporation into brain neurons - Dr.Jean Durlach

Dr. Glick suggests that Alzheimer's disease involves a defective transport process characterized by both an abnormally low Mg incorporation and an abnormally high Al incorporation into brain neurons.

Aluminum given to a healthy subject will bring on symptoms of tremors, forgetfulness, disorientation, a very dry, or weeping eczema and skin rashes, as well as other nerve and brain tissue disorders.

Magnesium protects cells from aluminium ,mercury, lead, cadmium, beryllium and nickel. Low magnesium is associated with glutathione depletion. This is vital since glutathione is one of the few antioxidant molecules known to neutralize mercury.

In an article recently published in the Journal of Orthomolecular Medicine, an Ontario study involving 668 autopsy-verified Alzheimer's brains, showed an increased risk by a factor of 2.5 in people drinking water with more than 100 micrograms of aluminium.
Blood brain barrier permeability:
The integrity and function of the BBB is critical for overall brain function. Changes in permeability often reflect alterations in BBB transport systems. Causes of generalized changes in BBB permeability include organic solvents, enzymes, heavy metals and free radicals.

Magnesium has an important role at the BBB and is the crucial nutrient that makes a big difference in prevention and treatment of Alzheimer’s disease

More benefits of Magnesium

Memory and the overall functioning of our brains depend on proteins in our brains called NMDA receptors, which allow our neurons to communicate with each other.

An understanding of the strategic importance of magnesium at these crucial NMDA receptor sites confirms the medical view that heavy magnesium supplementation would lead to better treatments for schizophrenia, Alzheimer’s disease, and stroke.

Magnesium permits calcium to enter a nerve cell to allow electrical transmission along the nerves to and from the brain. Even our thoughts, via brain neurons, are dependent on magnesium.
Dr. Carolyn Dean

Magnesium is essential in regulating central nervous system excitability. It calms the brain and people do not need to become severely deficient in magnesium for the brain to become hyperactive.

One study confirmed earlier reports that a marginal magnesium intake overexcites the brain's neurons and results in less coherence--creating cacophony rather than symphony--according to (EEG) measurements.

Of all the macronutrient minerals in the human body,
magnesium is the one most likely to be deficient.

Even a mild deficiency of magnesium can cause sensitiveness to noise, nervousness, irritability, mental depression, confusion, twitching, trembling, apprehension, and insomnia.

The two most basic requirements for the normal operation of our brain are a sufficient energy supply and an optimal presence of biochemicals involved in transmitting messages. Magnesium is crucial in both the production of energy and neurotransmitters and the integrity of the blood brain barrier. It is solid science that connects magnesium to neurological disorders.

Aging and Magnesium

Magnesium deficit and stress aggravate each other in a true 'pathogenic vicious circle', particularly in the stressful state of ageing. http://www.mg12.info/articles/ageing.html

Magnesium is the ‘rejuvenation’ mineral and in ancient China is called the beautiful metal that will bring only beauty to one’s life, body and skin.

According to Dr. J. Durlach, the biological clock and magnesium status are linked

Apply to face and any other area of body to help reduce wrinkles, apply to scalp to help rejuvenate hair, sometimes white/grey hair will move back towards its natural colour and bald patches re-grow.
(John Claydon D.Hom, founder of Regenerative Nutrition)

Rubbed regularly onto age spots will often cause them to fade and virtually disappear.
http://www.curesnaturally.com/Articles/Misc/Misc116.html

Dr. Mildred Seelig postulated that magnesium deficiency increases morbidity and mortality. “Little attention has been paid to special magnesium needs of old people, to whether magnesium inadequacy might contribute to the aging process, or to whether magnesium supplementation might have any beneficial effects in the aged”.



We may say that our biochemical age is determined by the ratio of magnesium to calcium within our cells.

On the biochemical level muscle contraction is triggered by calcium ions flowing into muscle cells. To relax the muscle calcium is pumped out again. However, as we age, more and more calcium remains trapped in the muscles and these become more or less permanently contracted, leading to increasing muscle tension and spasms.

Together with calcification of the joints, this is the typical rigidity and inflexibility of old age. The higher our intake of calcium relative to magnesium, the faster do we calcify and age. Most of the excess calcium in our diet ends up in our soft tissues and around joints leading to calcification with arthritic deformations, arteriosclerosis, cataracts, kidney stones and senility.

Dr Seyle proved experimentally that biochemical stress can lead to the pathological calcification of almost any organ. The more stress, the more calcification, the more rapid the aging.

 
Magnesium is the mineral of rejuvenation and prevents the calcification of our organs and tissues that is characteristic of the old-age related degeneration of our body.

As we age and most pronounced in old men and post-menopausal women, we become more and more inflexible. The arteries harden to cause arteriosclerosis, the skeletal system calcifies to cause rigidity with fusion of the spine and joints, kidneys and other organs and glands increasingly calcify and harden with stone formation, calcification in the eyes causes cataracts and even the skin hardens, becoming tough and wrinkled. In this way calcium is in the same league as oxygen and free radicals, while magnesium works together with hydrogen and the antioxidants to keep our body structure soft.

Rejuvenation by ingesting more magnesium is a slow process, especially as the amount of magnesium that we can take is limited by its laxative effect and the need to keep it in a reasonable balance with the calcium and phosphorus intake. The other problem is that spastic muscles have a poor blood and lymph circulation, which makes it difficult for the ingested magnesium to dissolve and flush out the tissue and joint calcifications.
http://www.curelibrary.com/blog/product-reviews/magnesium-chloride-for-health-and-rejuvenation-by-walter-last/

Magnesium deficit may participate in the clinical pattern of ageing, particularly in neuromuscular, cardiovascular and renal symptomatologies.

The consequences of hyperadrenoglucocorticism may include:

v    immunosuppression
v    muscle atrophy
v    centralization of fat mass
v    osteoporosis
v    hyperglycaemia
v    hyperlipidaemia
v    atherosclerosis
v    disturbances of mood and mental performance through accelerated hippocampal ageing particularly.

A positive correlation between energy intake and magnesium intake is always observed. This clinical observation of a decreased adaptability to stress due to ageing relies now on a rich and well-defined animal experimental background.

The age-related alterations in brain function particularly concern the hippocampal pyramidal neurones. This part of the limbic system exerts an inhibitory influence on the activity of the hypothalamo-pituitary-adrenal axis. Hippocampal ageing induces a state of hyperglucocorticism.

Target cells for glucocorticoids are more highly concentrated in the hippocampus than in any other brain region. Excess corticoid receptor activation mediates neuronal degeneration through an increased influx of calcium into the cells induced by a deleterious increased release of excitatory amino acids - such as kainic acid - associated with a decrease of protective inhibitory amino acids - such as glycine, GABA and taurine.

This new hippocampal injury could in turn provoke a new imbalance of the hypothalamo-pituitary-adrenal axis with a 'glucocorticoid cascade' inducing a state of hyperadrenoglucocorticism. The hippocampus is therefore a prime target area for investigation of the events which accompany stress and in particular for the regulation of stress-induced corticosteroid secretion.

But the hippocampus is also a basic structure for social life, being involved in mood regulation, control of internal inhibition, memory and learning. Long term potentiation of synaptic transmission in the hippocampus appears as its privileged investigation, too.

The differences between normal physiological ageing processes and pathological brain ageing processes may result from ageing-associated susceptibility factors: genetic predispositions, infections agents, environmental toxins or nutritional disorders.

Magnesium deficit could be one of these ageing-associated susceptibility factors, particularly through:
[1] the vicious circle initiated between magnesium and stress
[2] the relation between magnesium and neuroplasticity
[3] the links between magnesium and the hippocampus.

J. Durlach, V. Durlach, P. Bac, Y. Rayssiguier, M. Bara, and A. Guiet-Bara
Source:
www.mgwater.com

Some of the principle causes of magnesium deficiency in aging are gastrointestinal and renal losses. As we age, our kidneys lose their efficiency in regulation of magnesium. Magnesium absorption decreases with age. Around the age of seventy it becomes two-thirds of what it usually is at around the age of thirty.

Autism and Magnesium

Autistic children and children with other autistic spectrum disorders had significantly lower plasma concentrations of Mg than normal subjects.
Dr. M. Strambi

Doctors underestimate autistic children’s needs recommending only magnesium in oral form even though children with gut problems can absorb only small percentages through their intestines.

The entire autism community needs to be acutely aware that dependency on oral magnesium is responsible for less than excellent results. A complete changeover to transdermal magnesium supplementation is called for.

Why Transdermal?

·        Bypassing the stomach and liver means a much greater percentage of the active ingredient goes straight into the bloodstream where it’s needed.

When dealing with autism spectrum and other neurological disorders in children it is important to know the signs of low magnesium:

·        Restless/can’t keep still
·        body rocking
·        grinding teeth
·        hiccups
·        noise sensitive
·        poor attention span/concentration
·        irritable
·        aggressive/ready to explode
·        easily stressed

If magnesium levels become dramatically deficient we see symptoms such as convulsions, gross muscular tremor, muscular weakness, vertigo, excessive irritability, hallucinations, confusion, and semicoma.

When it comes to children today we need to assume a large magnesium deficiency for several reasons:

1) The foods they are eating are stripped of magnesium because foods in general are declining in mineral content in an alarming way.
2) The foods many children eat are highly processed junk foods that do not provide real nutrition to the body.
3) Because most children on the spectrum are not absorbing the minerals they need, even when present in the gut. Magnesium absorption is dependent on intestinal health, which is compromised totally in leaky gut syndromes and other intestinal problems that the majority of autism syndrome disorders.
4) Because the oral supplements doctors rely on are not easily absorbed, they are not in the right form and because magnesium in general is not administered easily orally.

Doctors have consistently found in autism a combination of conditions including severe intestinal dysbiosis, systemic fungal and viral infections, mineral deficiencies, abnormal serotonin levels and an abundance of toxic materials including pesticides other chemicals, mercury and other heavy metals. Autistic children are suffering from a heavy metal instigated gut and brain infections that create neurological dysfunctions.

Many children are born at risk for autism because they lack a healthy inner ecosystem at birth, lack the glutathione which removes the poisons from the cells

Low magnesium is associated with dramatic increases in free radical generation as well as glutathione depletion and this is vital since glutathione is one of the few antioxidant molecules known to neutralize mercury.

Recent research has pointed to low glutathione levels being responsible for children’s vulnerability to mercury poisoning from vaccines. Glutathione requires magnesium for its synthesis.

Impaired antioxidant production provides a common rationale
for many features of autistic disorders.

Higher use of oral antibiotics in the children with autism may explain the high incidence of chronic gastrointestinal problems and may also have reduced their ability to excrete mercury.

We know that mercury displaces essential elements like magnesium, selenium, zinc and copper from cells causing disruptions of enzyme systems in the process. So we can expect, when we correct nutritional deficiencies, that we will see a reversal in symptoms.

Children with autism had significantly (2.1-fold) higher levels of
mercury in their baby teeth. Children with autism also had significantly higher usage of oral antibiotics during their first 12 to 36 months of life.

Magnesium in general is essential for the survival of our cells but takes on further importance in the age of toxicity where our bodies are being bombarded on a daily basis with heavy metals.

Magnesium protects the brain from toxic effects of chemicals. Without sufficient magnesium, the body accumulates toxins and acid residues.

It is highly likely that low total body magnesium contributes to heavy metal toxicity in children and is a strong participant in the etiology of learning disorders.

Because of its nerve and muscle support, magnesium is helpful for nervousness, anxiety, insomnia, depression, and muscle cramps. Thus magnesium is also given as part of a treatment for autism or hyperactivity in kids. Children and adults tend to sleep better when taking magnesium before bed.

Extracted from www.magnesiumforlife.com

Massage oil

One of the most luxurious treatments on earth is to receive magnesium massages on a consistent basis
There are many ways to calm a person, many healing and medical treatments that can reduce stress, reduce sensory overload, slow the heart and help a person center and nothing does this better than touch. The most beautiful forms of touch are healing techniques and this is what professional massage therapists’ true aim is, to heal through touch. The skin provides the best avenue into the body for many medicinals.

When it comes to magnesium we have a method in our hands that is similar in effect to intravenous magnesium treatments that are used to save peoples’ lives in emergency rooms. We simply use the magnesium oil like we would massage oils, or create a special blend mixing essential oil or other massage oils together with the magnesium chloride, which is quite slippery even though there is no oil in the ‘magnesium oil.’

Massage therapists should be introducing their clients to the tremendous benefits of a magnesium massage and it is they who should suggest to their clients to start using it at home. Transdermal application of magnesium is superior to the commonly recommended oral magnesium supplements where absorption is typically poor.

In magnesium chloride oil we have a potent natural substance that penetrates the cells with stunning result on cell biochemistry and when loving touch is added to the mix the results are heartwarming to say the least.
http://magnesiumforlife.com/transdermal-magnesium/magnesium-oil/comment-page-1/#comment-3197


This is a powerful hydrotherapy that:
·        draws toxins from the tissues
·        replenishes the “vital fluid” of the cells
·        increases circulation
·        alleviates pain
·        calms the nervous system
·        relaxes skeletal muscles
·        draws inflammation out of the muscles and joints
 
Magnesium chloride, when applied directly to the skin, is transdermally absorbed and has an almost immediate effect on pain. It is also a natural tranquilizer that allows for deeper relaxation.

Combined with tissue manipulation during a massage, blood is brought closer to the surface of the skin, allowing faster absorption of magnesium into the cells.

For purposes of cellular detoxification and tissue purification, magnesium chloride has a strong excretory effect on toxins and stagnant energies stuck in the tissues of the body, drawing them out through the pores of the skin. This also assists in treating cellulite, which is caused by a build-up of toxins in the tissues.


Muscle Relaxant

Magnesium has a calming effect on the nerves as well as relaxing smooth and skeletal muscles.

It is a natural tranquilizer, easing tension and promoting relaxation throughout the body.

Rubbing liquid magnesium into the muscles provides faster relief from:
  • delayed onset muscle soreness (D.O.M.S)
  • spasms
  • cramps
  • back-ache
  • tension headaches
  • ‘trigger finger’
  • cramps associated with Irritable Bowel Syndrome (IBS)
Lamp of Life is ideal for athletes and anyone suffering with muscle tension and pain.  

ADHD and Magnesium

The Department of Family Medicine, Pomeranian Medical Academy, states that dietetic factors can play a significant role in the origin of ADHD and that magnesium deficiency can result in disruptive behaviors.

Even a mild deficiency of magnesium can cause:

increased sensitivity to noise
nervousness
irritability
mental depression
confusion
twitching
trembling
apprehension
insomnia

Researchers found that 95% of the 116 children affected with ADHD had magnesium deficiencies
(Magnesium Research 10(2): 143-148 1997)

In another study, just 200mg of elemental magnesium given to hyperactive children produced a noticeable decrease in hyperactivity over a 6 month period.
(Magnesium Research 10(2): 149-156 1997)

Several studies have shown a connection between magnesium and ADHD
1.Durlach J. Clinical aspects of chronic magnesium deficiency, in MS Seelig, Ed. Magnesium in Health and Disease. New York, Spectrum Publications, 1980.
2.Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res 10(2):143-8, 1997. 
3.Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res 10(2):143-8, 1997.
4.Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 10(2):149-56, 1997.

Magnesium is the premier medicine for depression, sleep disturbances, emotionally disturbed behavior, and neurological diseases because of its strong positive effect in calming and nourishing the nervous system.

It is essential in regulating central nervous system excitability thus a deficiency may cause aggressive behavior, depression, or suicide.

Magnesium permits calcium to enter a nerve cell to allow electrical
transmission along the nerves to and from the brain. Even our
thoughts, via brain neurons, are dependent on magnesium.
Dr. Carolyn Dean

The two most basic requirements for the normal operation of our brain are a sufficient energy supply and an optimal presence of biochemicals involved in transmitting messages. Magnesium is crucial in both the production of energy and neurotransmitters, and the integrity of the blood brain barrier. Solid neuroscience connects magnesium to neurological disorders.