Wednesday, September 29, 2010

Aging and Magnesium

Magnesium deficit and stress aggravate each other in a true 'pathogenic vicious circle', particularly in the stressful state of ageing. http://www.mg12.info/articles/ageing.html

Magnesium is the ‘rejuvenation’ mineral and in ancient China is called the beautiful metal that will bring only beauty to one’s life, body and skin.

According to Dr. J. Durlach, the biological clock and magnesium status are linked

Apply to face and any other area of body to help reduce wrinkles, apply to scalp to help rejuvenate hair, sometimes white/grey hair will move back towards its natural colour and bald patches re-grow.
(John Claydon D.Hom, founder of Regenerative Nutrition)

Rubbed regularly onto age spots will often cause them to fade and virtually disappear.
http://www.curesnaturally.com/Articles/Misc/Misc116.html

Dr. Mildred Seelig postulated that magnesium deficiency increases morbidity and mortality. “Little attention has been paid to special magnesium needs of old people, to whether magnesium inadequacy might contribute to the aging process, or to whether magnesium supplementation might have any beneficial effects in the aged”.



We may say that our biochemical age is determined by the ratio of magnesium to calcium within our cells.

On the biochemical level muscle contraction is triggered by calcium ions flowing into muscle cells. To relax the muscle calcium is pumped out again. However, as we age, more and more calcium remains trapped in the muscles and these become more or less permanently contracted, leading to increasing muscle tension and spasms.

Together with calcification of the joints, this is the typical rigidity and inflexibility of old age. The higher our intake of calcium relative to magnesium, the faster do we calcify and age. Most of the excess calcium in our diet ends up in our soft tissues and around joints leading to calcification with arthritic deformations, arteriosclerosis, cataracts, kidney stones and senility.

Dr Seyle proved experimentally that biochemical stress can lead to the pathological calcification of almost any organ. The more stress, the more calcification, the more rapid the aging.

 
Magnesium is the mineral of rejuvenation and prevents the calcification of our organs and tissues that is characteristic of the old-age related degeneration of our body.

As we age and most pronounced in old men and post-menopausal women, we become more and more inflexible. The arteries harden to cause arteriosclerosis, the skeletal system calcifies to cause rigidity with fusion of the spine and joints, kidneys and other organs and glands increasingly calcify and harden with stone formation, calcification in the eyes causes cataracts and even the skin hardens, becoming tough and wrinkled. In this way calcium is in the same league as oxygen and free radicals, while magnesium works together with hydrogen and the antioxidants to keep our body structure soft.

Rejuvenation by ingesting more magnesium is a slow process, especially as the amount of magnesium that we can take is limited by its laxative effect and the need to keep it in a reasonable balance with the calcium and phosphorus intake. The other problem is that spastic muscles have a poor blood and lymph circulation, which makes it difficult for the ingested magnesium to dissolve and flush out the tissue and joint calcifications.
http://www.curelibrary.com/blog/product-reviews/magnesium-chloride-for-health-and-rejuvenation-by-walter-last/

Magnesium deficit may participate in the clinical pattern of ageing, particularly in neuromuscular, cardiovascular and renal symptomatologies.

The consequences of hyperadrenoglucocorticism may include:

v    immunosuppression
v    muscle atrophy
v    centralization of fat mass
v    osteoporosis
v    hyperglycaemia
v    hyperlipidaemia
v    atherosclerosis
v    disturbances of mood and mental performance through accelerated hippocampal ageing particularly.

A positive correlation between energy intake and magnesium intake is always observed. This clinical observation of a decreased adaptability to stress due to ageing relies now on a rich and well-defined animal experimental background.

The age-related alterations in brain function particularly concern the hippocampal pyramidal neurones. This part of the limbic system exerts an inhibitory influence on the activity of the hypothalamo-pituitary-adrenal axis. Hippocampal ageing induces a state of hyperglucocorticism.

Target cells for glucocorticoids are more highly concentrated in the hippocampus than in any other brain region. Excess corticoid receptor activation mediates neuronal degeneration through an increased influx of calcium into the cells induced by a deleterious increased release of excitatory amino acids - such as kainic acid - associated with a decrease of protective inhibitory amino acids - such as glycine, GABA and taurine.

This new hippocampal injury could in turn provoke a new imbalance of the hypothalamo-pituitary-adrenal axis with a 'glucocorticoid cascade' inducing a state of hyperadrenoglucocorticism. The hippocampus is therefore a prime target area for investigation of the events which accompany stress and in particular for the regulation of stress-induced corticosteroid secretion.

But the hippocampus is also a basic structure for social life, being involved in mood regulation, control of internal inhibition, memory and learning. Long term potentiation of synaptic transmission in the hippocampus appears as its privileged investigation, too.

The differences between normal physiological ageing processes and pathological brain ageing processes may result from ageing-associated susceptibility factors: genetic predispositions, infections agents, environmental toxins or nutritional disorders.

Magnesium deficit could be one of these ageing-associated susceptibility factors, particularly through:
[1] the vicious circle initiated between magnesium and stress
[2] the relation between magnesium and neuroplasticity
[3] the links between magnesium and the hippocampus.

J. Durlach, V. Durlach, P. Bac, Y. Rayssiguier, M. Bara, and A. Guiet-Bara
Source:
www.mgwater.com

Some of the principle causes of magnesium deficiency in aging are gastrointestinal and renal losses. As we age, our kidneys lose their efficiency in regulation of magnesium. Magnesium absorption decreases with age. Around the age of seventy it becomes two-thirds of what it usually is at around the age of thirty.

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